Geometry of Genome:

Unravelling of Structures Hidden in Genomic Sequences

Leicester, UK, 22/09/2005 – 24/09/2005

DNA WALK: Trajectory of triplet usage in dataspace
Helicobacter pylori, A Zinovyev,2002,
http://www.ihes.fr/~zinovyev/

Deadlines:

Abstract Submission: April 30, 2005
(extended)

Acceptance: May 15, 2005;

Hotel Booking: June 15, 2005

Contact address:

gg@mcs.le.ac.uk

The post-genomic era is characterized by the knowledge of hundreds of completed genomic sequences. Analysis of these sequences shows that there are common principles of organization of sequence information. Some of the most powerful methods available for understanding these principles are based on the geometric representation of genome features. That is, one can study properties of genomic sequences by representing them in multidimensional spaces defined by their local properties. In most cases these representations appear to be structured and organized in a complex hierarchical way.

Methods from a variety of scientific disciplines, such as dimensional reduction and data visualization, as well as methods dealing with the geometry of multidimensional spaces help to detect and analyze the structures. The geometric representation is also an important tool for data mining.

This workshop will bring together biologists, physical scientists and mathematicians to examine representative challenges, and necessary tools for level jumping and generalization.

The workshop will include key talks, intensive round-table discussions, and the special procedures such as brainstorming sessions are also planned.

The particular projects to be discussed:

1. Development of International partnerships in Geometry of Genome research.

2. Establish the foundation of the scientific discipline with a publication of a book of review articles on “Geometry of Genome”, as well as in the web-servers “Geometry of Genome” (first, on the basis of existing servers).

3. Preparation of a textbook for the training in the discipline “Geometry of Genome”

This list will be certainly extended by the Workshop participants during the Workshop.

Key participants

Professor Alexander Bolshoy

Genome Diversity Center, Faculty of Sciences

University of Haifa, Israel

http://research.haifa.ac.il/~genom/Alex's_page/
ABSTRACT

Professor Alessandra Carbone
Equipe de Génomique Analytique, Faculty of Medicine and Department of
Computer Science, Université Pierre et Marie Curie, France
http://www.ihes.fr/~carbone/Index.htm
http://www.ihes.fr/~carbone/

ABSTRACT

Professor Stanislaw Cebrat

Institute of Genetics and Microbiology
Wrocław University, Poland

http://smorfland.microb.uni.wroc.pl/~cebrat/
ABSTRACT

Professor Chun-Ting Zhang

Bioinformatic Center, Dept Physics,

Tianjin University, China
ABSTRACT

Professor David Epstein

Warwick Mathematics Institute

University of Warwick, Coventry, UK

http://www.maths.warwick.ac.uk/~dbae/

Professor Alexander Gorban

Centre for Mathematical Modelling,

Department of Mathematics

University of Leicester, UK

http://www.math.le.ac.uk/~ag153/
ABSTRACT

Professor Laurent GUÉGUEN
UMR CNRS 5558 Biometrie et Biologie Evolutive
Universite Claude Bernard - Lyon 1,
FRANCE
http://biomserv.univ-lyon1.fr/
ABSTRACT

Professor Pat Heslop-Harrison

Department of Biology,

University of Leicester, UK

http://www.le.ac.uk/biology/phh4/

ABSTRACT